Publications


2009 | 2008 | 2007 |2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 | 1992 | 1991 | Before 1990 |

2009

(Top»)

  1. Kerckhoffs RCP, Mulligan LJ (2009) Computational modeling of heart failure with application to cardiac resynchronization therapy. Book Chapter In: Computational Cardiovascular Mechanics: Modeling and Applications in Heart Failure Eds. Guccione, J. & Ratcliffe M. (in press)

  2. Neal ML, Kerckhoffs RCP (2009) Current Progress in Patient-Specific Modeling. Briefings in Bioinformatics (in press)

  3. Feala JD, Coquin L, Zhou D, Haddad GG, Paternostro G, McCulloch AD (2009) Metabolism as means for hypoxia adaptation: Metabolic profiling and flux balance analysis. BMC Systems Biology 3:91

  4. Jacot JG, Raskin AJ, Omens JH, McCulloch AD & Tung L. Mechanotransduction in Cardiac and Stem Cell Derived Cardiac Cells. Book Chapter In: Mechanosensitivity in Cells and Tissues 4th ed.. eds. Kamkin A. & Kiseleva I. (in press).

  5. Jacot JJ, Kita-Matsuo H, Wei K, Chen HSV, Omens JH, Mercola M, McCulloch AD (2009)Cardiac myocyte force development during differentiation and maturation. Ann NY Acad Sci (in press)

  6. Feala JD, Cortes J, Duxbury PM, Piermarocchi C, McCulloch AD, Paternostro G (2009) Systems approaches and algorithms for discovery of combinatorial therapeutics. Wiley Interdisciplinary Reviews: Systems Biology and Medicine (in press)

  7. Kita-Matsuo H, Barcova M, Prigozhina N, Salomonis N, Wei K, Jacot JG, Nelson B, Spiering S, Haverslag R, Kim C, Talantova M, Bajpai R, Calzolari D, McCulloch AD, Price JH, Conklin BR, Chen HSV, Mercola M (2009) Lentiviral vectors and protocols for creation of stable hESC lines for fluorescent tracking and drug resistance selection of cardiomyocytes. PLoS One 4(4):e5046. Epub 2009 Apr 8. PMID: 19352491

  8. Campbell SG, Howard EJ, Aguado-Sierra J, Coppola BA, Omens JH, Mulligan LJ, McCulloch AD, Kerckhoffs RCP (2009) Effect of transmurally heterogeneous myocyte excitation-contraction coupling on canine left ventricular electromechanics. Experimental Physiology 2009;94(5):541-552 DOI: 10.1113/expphysiol.2008.044057

  9. Lu S, Michailova A, Saucerman J, Cheng Y, Yu Z, Kaiser T, Li W, Bank RE, Holst M, McCammon JA, Hayashi T, Hoshijima M, Arzberger P, McCulloch AD (2008) Multi-scale modeling in rodent ventricular myocytes: Contributions of structural and functional heterogeneities to excitation-contraction coupling. IEEE Engineering in Medicine and Biology 2009;Mar/Apr:46-57 DOI: 10.1109/MEMB.2009.931787

2008

(Top»)

  1. Calzolari D, Bruschi S, Coquin L, Schofield J, Feala JD, Reed JC, McCulloch AD, Paternostro G (2008) Search algorithms as a framework for the optimization of drug combinations. PLoS Comput Biol 2008 Dec;4(12):e1000249. Epub 2008 Dec 26. PMID: 19112483

  2. Coquin L, Feala JD, McCulloch AD, Paternostro G (2008) Metabolomic and flux-balance analysis of age-related decline of hypoxia tolerance in Drosophila muscle tissue. Mol Syst Biol 2008;4:233. Epub 2008 Dec 16. PMID: 19096360

  3. Sheikh F*, Raskin A*, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW 2nd, Heller-Brown J, Peterson KL, Omens JH, McCulloch AD, Chen J (2008) An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest 2008 Dec;118(12):3870-80. doi: 10.1172/JCI34472. Epub 2008 Nov 3. *authors contributed equally

  4. Mills RW, Narayan SM, McCulloch AD. Mechanisms of Conduction Slowing During Myocardial Stretch by Ventricular Volume Loading in Rabbit. Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H1270-H1278. PMID: 18660447

  5. Rudy Y, Ackerman MJ, Bers DM, Clancy CE, Houser SR, London B, McCulloch AD, Przywara DA, Rasmusson R, Solaro J, Trayanova N, Van Wagoner DR, Varro A, Weiss JN, Lathrop DA (2008) Systems approach to understanding electromechanical activity in the human heart: A National Heart, Lung, and Blood Institute workshop summary. Circulation 2008 Sep 9;118(11):1202-11

  6. Raskin A, Hoshijima M, Swanson E, McCulloch A, Omens J (2008) Hypertrophic Gene Expression Induced by Chronic Stretch of Excised Mouse Heart Muscle MCB 2008;(in press)

  7. Jacot JJ, McCulloch AD, Omens JH (2008) Substrate stiffness affects the functional maturation of neonatal rat ventricular myocytes. Biophys J 2008 Oct;95(7):3479-87. Epub 2008 Jun 27

  8. Lim B-K*, Xiong D*, Dorner A*, Youn T-J, Yung A, Liu TI, Gu Y, Dalton ND, Wright AT, Evans SM, Chen J, Peterson KL, McCulloch AD, Yajima T, Knowlton KU (2008) Coxsackievirus and adenovirus receptor (CAR) in the heart is essential for atrioventricular-node function and localization of connexin 45. JCI 2008;118(8):2758-70 *authors contributed equally

  9. Cai CL*, Martin JC*, Sun Y*, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X, Stallcup WB, Denton CP, McCulloch AD, Chen J, Evans SM (2008) A myocardial lineage derives from Tbx18 epicardial cells. Nature 2008;454:104-108 (3 July 2008) doi:10.1038/nature06969. *authors contributed equally

  10. Campbell SG, Flaim SN, Leem CH, McCulloch AD (2008) Mechanisms of transmurally-varying myocyte electromechanics in an integrated computational model. Phil Trans Royal Soc A 2008 Sep;366(1879):3361-3380 doi:10.1098/rsta.2008.0088 (published online 1 July 2008)

  11. Kerckhoffs RCP, Narayan SM, Omens JH, Mulligan LJ, McCulloch AD (2008) Computational modeling for bedside application. Heart Failure Clinics 4:371-378

  12. Michailova A, McCulloch A (2008) Effects of Mg2+, pH and PCr on cardiac excitation-metabolic coupling. Magnesium Research March 2008;21(1):16-28

  13. Kerckhoffs RCP, McCulloch AD, Omens JH, Mulligan LJ (2008) Effects of biventricular pacing and scar size in a computational model of the failing heart with left bundle branch block. (2009) Medical Image Analysis 13: 362-369.

  14. Kerckhoffs RCP, Lumens J, Vernooy K, Omens JH, Mulligan LJ, Delhaas T, Arts T, McCulloch AD, Prinzen FW (2008) Cardiac Resynchronization: insight from experimental and computational models. Progress in Biophysics and Molecular Biology Jun-Jul 2008;97:543-561. doi:10.1016/j.pbiomolbio.2008.02.024

  15. *Campbell PH, *Hunt DL, Jones Y, Harwood F, Amiel D, Omens JH, McCulloch AD (2008) Effects of biglycan deficiency on myocardial infarct structure and mechanics. MCB: Molecular & Cellular Biomechanics 2008;5(1):27-36 (*equal contributors)

  16. Li W, Gurev V, McCulloch AD, Trayanova NA (2008) The role of mechanoelectric feedback in vulnerability to electric shock.Progress in Biophysics and Molecular Biology 2008 Feb 16;97:461-478. doi:10.1016/j.pbiomolbio.2008.02.020 (online before print)

  17. Zhang Y, Sekara RB, McCulloch AD, Tung L (2008) Cell cultures as models of cardiac mechanoelectric feedback. Progress in Biophysics and Molecular Biology Feb 16, 2008;97:367–382 PMID: 18384846 (online before print)

  18. Feala JD, Omens JH, Paternostro G, McCulloch AD (2008) Discovering regulators of the drosophila cardiac hypoxia response using automated phenotyping technology.Ann NY Acad Sci 2008;1123:169-177

  19. Feala J, McCulloch AD, Coquin L, Paternostro G (2008) Integrating metabolomics and phenomics with systems models of cardiac hypoxia. Prog Biophys Molec Biol 96(1-3):209-225; PMID: 17870149

2007

(Top»)

  1. Flaim SN, McCulloch AD (2007) Acetylcholine-induced shortening of the epicardial APD may increase repolarization gradients and LQT3 arrhythmic risk. J Electrocardiol 2007;40:S66-69

  2. Zemljic-Harpf AE, Miller JC, Henderson SA, Wright AT, Manso AM, Elsherif L, Dalton ND, Thor AK, Perkins GA, McCulloch AD, Ross RS (2007) Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy. Mol Cell Biol 2007 Nov;27(21):7522-37

  3. Ingrassia CM, Usyk TP, Kerckhoffs RCP, McCulloch AD, Costa KD, Holmes JW (2007) Model-based development of four-dimensional wall motion measures. Computer Methods in Applied Mechanics and Engineering 15 Jun 2007;196(31-32):3061-3069

  4. Flaim SN, Giles WR, McCulloch AD (2007) Arrhythmogenic consequences of Na+ channel mutations in the transmurally heterogeneous mammalian left ventricle: An analysis of the I1768V SCN5A mutation. Heart Rhythm Jun 2007;4:768-778

  5. Broderick K, Potluri P, Feala J, McCulloch AD, Bigby T, Belke D, Boss G (2007) The cobalamin precursor cobinamide detoxifies nitroprusside-generated cyanide. Experimental Biology and Medicine 2007;232:789-798

  6. Coppola BA, Covell JW, McCulloch AD, Omens JH (2007) Asynchrony of ventricular activation affects magnitude and timing of fiber stretch in late-activated regions of the canine heart. Am J Physiol Heart Circ Physiol 2007 Jul;293(1):H754-61. Epub 2007 Apr 20.

  7. Costandi PN, McCulloch AD, Omens JH, Frank LR (2007) High-resolution longitudinal MRI of the transition to heart failure. Magnetic Resonance in Medicine 2007 Apr;57(4):714-20

  8. Feala J, Coquin L, McCulloch AD, Paternostro G (2007) Flexibility in energy metabolism supports hypoxia tolerance in Drosophila flight muscle: metabolomic and computational systems analysis. Molecular Systems Biology 17 Apr 2007;3:99. (doi:10.1038/msb4100139)

  9. Michailova AP, Lorentz W, McCulloch AD (2007) Modeling transmural heterogeneity of KATP current in rabbit ventricular myocytes. Am J Physiol Cell Physiol, Feb 2007;293:542-557 doi:10.1152/ajpcell.00148.2006

  10. Kerckhoffs RCP, Neal M, Gu Q, Bassingthwaighte JBB, Omens JH, McCulloch AD (2007) Coupling of a three-dimensional finite element model of cardiac ventricular mechanics to lumped systems models of the systemic and pulmonic circulation. Ann Biomed Eng Jan 2007;35(1):1-18

  11. Kerckhoffs RCP, McCulloch AD (2007) Cardiac Electromechanics in the Healthy Heart In: An Introductory Text to Bioengineering. Chien et al (Eds). World Scientific Publishing Co., Singapore. (in press)

2006

(Top»)

  1. Kerckhoffs RCP, Healy SN, Usyk TP, McCulloch AD (2006) Computational methods for modeling cardiac electromechanics. Proc IEEE April 2006;94(4):769-783

  2. Hunter PJ, Li W, McCulloch AD, Noble D (2006) Multiscale modeling: Physiome project standards, tools, and databases. IEEE Computer 2006;39(11):48-54

  3. Camelliti P, Gallagher JO, Kohl P, McCulloch AD (2006) Micropatterned cell cultures on elastic membranes as an in-vitro model of myocardium. Nature Protocols 02 Nov 2006;1(3):1379-1391

  4. Saucerman JJ, McCulloch AD (2006) Cardiac β-adrenergic signaling: from subcellular microdomains to heart failure. Ann NY Acad Sci 1080:348-361

  5. Flaim SN, Giles WR, McCulloch AD (2006) Contributions of sustained INa and IKv4.3 to transmural heterogeneity of early repolarization and arrhythmogenesis in canine left ventricular myocytes. Am J Physiol Heart Circ Physiol 2006;291(6):H2617-29

  6. Costandi PN, Frank LR, McCulloch AD, Omens JH (2006) Role of diastolic properties in the transition to failure in a mouse model of cardiac dilatation. Am J Physiol Heart Circ Physiol 2006;291(6):H2971-9

  7. Saucerman JJ, Zhang J, Martin JC, Peng LX, Stenbit AE, Tsien RY, McCulloch AD (2006) Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes. Proc Nat Acad Sci 103(34):12923-12928

  8. Li W, Baker N, Baldridge K, McCammon JA, Ellisman MH, Gupta A, Holst M, McCulloch AD, Michailova AP, Papadopoulos P, Olson A, Sanner M, Arzbereger PW (2006) National Biomedical Computation Resource (NBCR): Developing End-to-End Cyberinfrastructure for Multiscale Modeling in Biomedical Research. CTWatch Quarterly August 2006;2(3) http://www.ctwatch.org/quarterly/articles/2006/08/national-biomedical-computation-resource/

  9. Lorenzen-Schmidt I, Schmid-Schonbein GW; Giles WR, McCulloch AD, Chien S, Omens JH (2006) Chronotropic response of cultured neonatal rat ventricular myocytes to short-term fluid shear. Cell Biochem Biophys 2006;46(2):113-22.

  10. Broderick KE, Feala J, McCulloch A, Paternostro G, Sharma VS, Pilz RB, Boss GR (2006) The nitric oxide scavenger cobinamide profoundly improves survival in a Drosophila melanogaster model of bacterial sepsis. FASEB J 2006 20: 1865-1873

  11. McCulloch AD, Arzberger P, Hunter P (2006) Computational Physiology: From Genome to Physiome. The Physiologist 2006;49(1):94-95

  12. McCulloch AD, Omens JH (2006) Myocyte shearing, myocardial sheets, and microtubules. Circ Res 2006 Jan 6;98(1):1-3

2005

(Top»)

  1. Healy SN, McCulloch AD (2005) An ionic model of stretch-activated currents in rabbit ventricular myocytes. Europace 2005;7:S128-134

  2. Lorenzen-Schmidt I, Stuyvers BD; ter Keurs HEDJ, Date M-o, Hoshijima M, Chien KR, McCulloch AD, Omens JH (2005) Young MLP deficient mice show diastolic dysfunction before the onset of dilated cardiomyopathy. J Molec Cell Cardiol 2005;39(2):241-50

  3. Lorenzen-Schmidt I, McCulloch AD, Omens JH (2005) Deficiency of actinin-associated LIM protein alters regional right ventricular function and hypertrophic remodeling. Ann Biomed Eng 2005;33:888-896

  4. Camelliti P, McCulloch AD, Kohl P (2005) Microstructured cocultures of cardiomyocytes and fibroblasts: a two-dimensional in vitro model of cardiac tissue. Microscopy and Microanalysis 2005 Jun;11(3):249-259

  5. Weis SM, Zimmerman SD, Shah M, Covell JW, Omens JH, Ross J, Jr., Dalton N, Jones Y, Reed CC, Iozzo RV, McCulloch AD (2005) A role for decorin in the remodeling of myocardial infarction, Matrix Biology 2005 Jun;24(4):313-324

  6. McCulloch AD, Paternostro G (2005) Cardiac systems biology. Ann NY Acad Sci Jun 2005;1047: 283-295.

  7. Michailova AP, Saucerman JJ, Belik ME, McCulloch AD (2005) Modeling regulation of cardiac KATP and L-type Ca2+ currents by ATP, ADP and Mg2+. Biophysical Journal 88:2234-2249

  8. Ferrarini L, Bertelli L, Feala J, McCulloch AD, Paternostro G (2005) A more efficient search strategy for aging genes based on connectivity. Bioinformatics 2005 Feb 1;21(3):338-48

  9. Mills RW, Narayan SM, McCulloch AD (2005) The effects of wall stretch on ventricular conduction and refractoriness in the whole heart. Chapter 14 in Kohl P, Sachs F, Franz MR (Editors) Cardiac Mechano-Electric Feedback and Arrhythmias: From Pipette To Patient. Elsevier Saunders: Philadelphia, pages 127-136

2004

(Top»)

  1. McCulloch AD (2004) Functionally and structurally integrated computational modeling of ventricular physiology. Jpn J Physiol 2004 Dec;54(6):531-9

  2. Saucerman JJ, Healy SN, Belik ME, Puglisi JL, McCulloch AD (2004) Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: computational models of whole cells and heterogeneous tissue. Circulation Research 2004 Dec 10;95(12):1216-24

  3. Chen L, McCulloch AD, May-Newman KD (2004) Nonhomogeneous deformation in the anterior leaflet of the mitral valve. J Biomech Eng 2004 Dec;32(12):1599-606

  4. Buckberg GD, Weisfeldt ML, Ballester M, Beyar R, Burkhoff D, Coghlan HC, Doyle M, Epstein ND, Gharib M, Ideker RE, Ingels NB, LeWinter MM, McCulloch AD, Pohost GM, Reinlib LJ, Sahn DJ, Spinale FG, Spotnitz HM, Sopko G, Torrent-Guasp F, Shapiro EP (2004) Left Ventricular Form and Function: Scientific Priorities and Strategic Planning for Development of New Views of Disease. Circulation 004;110:e333-e336

  5. Michailova AP, Belik ME, and McCulloch AD (2004) Effects of magnesium on cardiac excitation-contraction coupling. Journal of American College of Nutrition 2004;23(5): 514S-517S

  6. Saucerman JJ, McCulloch AD (2004) Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation. Prog Biophys Molec Biol 2004;85(2/3):261-278

  7. Shah S, Davis J, Weisleder N, Kostavassili I, McCulloch AD, Ralston E, Capetanaki Y, Lieber RL (2004) Structural and functional roles of desmin in mouse skeletal muscle during passive deformation. Biophys J 2004 May;86(5):2993-3008

  8. Belik ME, Usyk TP, McCulloch AD (2004) Computational methods for cardiac electrophysiology. In (Ayache N, Guest Ed) Computational Models for the Human Body, Special Volume of (Ciarlet PG, Ed) Handbook of Numerical Analysis, Volume XII. Elsevier B.V., pp. 129-188

2003

(Top»)

  1. Usyk TP, McCulloch AD (2003) Electromechanical model of cardiac resynchronization in the dilated failing heart with left bundle branch block. J Electrocardiol 2003;36(suppl):57-61

  2. Omens JH, McCulloch AD, Criscione JC (2003) Complex distributions of residual stress and strain in the mouse left ventricle: experimental and theoretical models. Biomechanics and Modeling in Mechanobiology 1(4):267-277

  3. Usyk TP, McCulloch AD (2003) Relationship between regional shortening and asynchronous electrical activation in a three-dimensional model of ventricular electromechanics. J Cardiovasc Electrophysiol 14(suppl): S196-S202

  4. Saucerman JJ, Brunton LL, Michailova AP, McCulloch AD (2003) Modeling β-adrenergic control of cardiac myocyte contractility in silico. J Biol Chem, Nov 2003; 278: 47997 – 48003

  5. Sung D, Mills RW, Schettler J, Narayan SM, Omens JH, McCulloch AD (2003) Ventricular filling slows epicardial conduction and increases action potential duration in an optical mapping study of the isolated rabbit heart. J Cardiovasc Electrophysiol 2003;14(7):739-749

  6. Herrmann KL, McCulloch AD , Omens JH (2003) Glycated collagen cross-linking alters cardiac mechanics in volume-overload hypertrophy. Am J Physiol Heart Circ Physiol 284(4): H1277-84.

  7. Gopalan SM, Flaim C, Bhatia SN, Hoshijima M, Knoell R, Chien KR, Omens JH, McCulloch AD (2003) Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers. Biotechnol Bioeng 2003;81:578-587

  8. Usyk TP, McCulloch AD (2003) Computational methods for soft tissue biomechanics. In Holzapfel GA, Ogden RW (Eds) Biomechanics of Soft Tissue in Cardiovascular Systems. Springer, Wien New York (CISM Courses and Lectures No. 441, International Center for Mechanical Sciences), pages 273-342

  9. Humphrey JD, McCulloch AD (2003) The cardiovascular system – anatomy, physiology and cell biology. In Holzapfel GA, Ogden RW (Eds) Biomechanics of Soft Tissue in Cardiovascular Systems. Springer, Wien New York (CISM Courses and Lectures No. 441, International Center for Mechanical Sciences), pages 273-342

2002

(Top»)

  1. Knöll R, Hoshijima M, Hoffman HM, Person V, Lorenzen-Schmidt I, Bang M-L, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork NJ, Omens JH, McCulloch AD, Kimura A, Gregorio CC, Poller W, Schaper J, Schultheiss HP, Chien KR (2002) The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell 2002;111:943–955

  2. Sussman MA, McCulloch A, Borg TK (2002) Dance band on the Titanic: biomechanical signaling in cardiac hypertrophy. Circ Res 2002;91:888-898

  3. Stuyvers BD, McCulloch AD, Guo J, Duff HJ, ter Keurs HEDJ (2002) Effect of stimulation rate, sarcomere length and Ca2+ on force generation of mouse cardiac muscle. J Physiol (Lond) 544.3:817-830

  4. McCulloch AD, Huber G (2002) Integrative biological modelling in silico. In: Bock G, Goode JA, eds. ‘In silico’ simulation of biological processes. Wiley, Chichester (Novartis Foundation Symposium 247), pages 4-25

  5. Omens JH, Usyk TP, Li Z, McCulloch AD (2002) Muscle LIM protein deficiency leads to alterations in passive ventricular mechanics. Am J Physiol Heart Circ Physiol 2002;282:H680-H687

  6. Usyk TP, LeGrice IJ, McCulloch AD (2002) Computational model of three-dimensional cardiac electromechanics. Comput Visual Sci 2002;4(4):249-257

  7. Criscione JC, McCulloch AD, Hunter WC (2002) Constitutive framework optimized for myocardium and other high-strain, laminar materials reinforced with one family of fibers. Journal of the Mechanics and Physics of Solids Jun 2002;50(8):1681-1702

2001

(Top»)

  1. Gregersen H, Weis SM, McCulloch AD (2001) Oesophageal morphometry and residual strain in a mouse model of osteogenesis imperfecta. Neurogastroenterol Mot 2001;13:457-464.

  2. Baxter WW, McCulloch AD (2001) Finite element model-based image analysis of pacemaker lead mechanics in vivo. Medical Image Analysis December 2001;5(4):255-270

  3. Sung D, Somayajula-Jagai J, Cosman P, Mills RW, McCulloch AD (2001) Phase-shifting prior to spatial filtering enhances optical recordings of cardiac action potential propagation. Ann Biomed Eng 2001;29:854-861

  4. Michailova A, McCulloch AD (2001) Model study of ATP and ADP buffering, transport of Ca2+ and Mg2+, and regulation of ion pumps in ventricular myocytes. Biophys J 81(2):614-629

  5. McCulloch AD, Sung D, Thomas ME, Michailova M (2001) Experimental and Computational Modeling of Cardiac Electromechanical Coupling. In: T Katila, IE Magnin, P Clarysse, J Montagnet, J Nenonen, Eds. Functional Imaging and Modeling of the Heart. Lecture Notes in Computer Science 2230, Springer-Verlag, Berlin, pages 113-119.

  6. Mazhari R, Omens JH, Pavelec RS, Covell JW, McCulloch AD (2001) Transmural distribution of three-dimensional systolic strains in stunned myocardium. Circulation 104(3):336-341.

  7. Usyk TP, Omens JH, McCulloch AD (2001) Regional septal dysfunction in a three-dimensional computational model of focal myofiber disarray. Am J Physiol Heart Circ Physiol 281:H506-H514.

  8. McCulloch AD, Mazhari R (2001) Regional ventricular mechanics: Integrative computational models of myocardial flow-function relations. J Nucl Cardiol 8:506-19.

  9. McCulloch AD, Sung D, Thomas ME, Michailova M (2001) Computational and Experimental Modeling of Ventricular Electromechanical Interactions. Chapter 11 in: N Virag, O Blanc and L Kappenberger, Eds. Computer Simulation and Experimental Assessment of Cardiac Electrophysiology. Futura Publishing, Armonk, NY, pages 89-96.

  10. Vetter FJ, McCulloch AD (2001) Mechanoelectric feedback in a model of the passively inflated left ventricle. Annals Biomed Eng 29:414-426 (and cover)

  11. Costa KD, Holmes JW, McCulloch AD (2001) Modeling cardiac mechanical properties in three dimensions. Phil Trans R Soc Lond A 359:1233-1250

  12. McCulloch AD (2001) Regional stress and strain in healthy and diseased ventricular myocardium. Chapter 1 in: Amini AA, Prinz JL (eds), Measurement of Cardiac Deformations from MRI: Physical and Mathematical Models. Kluwer Academic Publishers, New York, NY, pages 1-15

  13. Paternostro G, Vignola C, Bartsch DU, Omens JH, McCulloch AD, Reed JC (2001) Age-associated cardiac dysfunction in Drosophila melanogaster: Implications for genetic screening. Circ Res 88:1053-1058.

  14. Arts T, Costa KD, Covell JW, McCulloch AD (2001) Relating myocardial laminar architecture to shear strain and muscle fiber orientation. Am J Physiol: Heart Circ Physiol 280(5):H2222-H2229

  15. Ramakrishna R, Edwards JS, McCulloch AD, Palsson BO (2001) Flux balance analysis of mitochondrial energy metabolism: consequences of systemic stoichiometric constraints. Am J Physiol Regulatory Integrative Comparative Physiol 280:R695-R704.

2000

(Top»)

  1. Usyk TP, Mazhari R, McCulloch AD (2000) Effect of laminar orthotropic myofiber architecture on regional stress and strain in the canine left ventricle. J Elasticity 61(1/3):143-164.

  2. Young AA, Dokos S, Powell KA, Sturm B, McCulloch AD, Starling RC, McCarthy PM, White RD (2001) Usyk TP, Mazhari R, McCulloch AD (2000) Regional heterogeneity of function in nonischemic dilated cardiomyopathy. Cardiovasc Res 49(2):308-318

  3. McCulloch AD (2000) Modeling the human cardiome in silico. J Nucl Cardiol Sep-Oct;7(5):496-9 (Editorial)

  4. Sung D, Omens JH, McCulloch AD (2000) Model-based analysis of optically mapped epicardial activation patterns and conduction velocity. Ann Biomed Eng 28(9):1085-1092

  5. Mazhari R, McCulloch AD (2000) Integrative models for understanding the structural basis of regional mechanical dysfunction in ischemic myocardium. Ann Biomed Eng 28(8):979-990

  6. Weis SM, Emery JL, Becker KD, McBride DJ Jr, Omens JH, McCulloch AD (2000) Myocardial mechanics and collagen structure in the osteogenesis imperfecta murine. Circ Res 87;663-669.

  7. Vetter FJ, McCulloch AD (2000) Three-dimensional stress and strain in passive rabbit left ventricle: A model study. Annals of Biomed Eng 28:781-792

  8. McCulloch AD (2000) Cardiac Biomechanics. Chapter 28, Section III in: The Biomedical Engineering Handbook, 2nd Edition, Volume I, Bronzino JD, Editor-in-Chief, CRC Press, Boca Raton, FL: pages 28-1 – 28-26.

  9. O'Dell WG, McCulloch AD (2000) Imaging three-dimensional cardiac function. Ann Rev Biomedical Engineering 2: 431-456

  10. Mazhari R, Omens JH, Covell JW, McCulloch AD (2000) Structural basis of regional dysfunction in acutely ischemic myocardium. Cardiovasc Res 47:284-293.

  11. Karlon WJ, McCulloch AD, Covell JW, Hunter JJ, Omens JH (2000) Regional dysfunction correlates with myofiber disarray in transgenic mice with ventricular expression of ras. Am J Physiol: Heart Circ Physiol 278(3): H898-H906.

1999

(Top»)

  1. Karlon WJ, Hsu PP, Li S, Chien S, McCulloch AD, Omens JH (1999) Measurement of orientation and distribution of cellular alignment and cytoskeletal organization. Ann Biomed Eng 27(6): 712-20.

  2. Lee AA, Delhaas T, McCulloch AD, Villarreal FJ (1999) Differential responses of adult cardiac fibroblasts to biaxial strain patterns. J Mol Cell Cardiol 31(10):1833-43.

  3. Costa KD, Takayama Y, McCulloch AD, Covell JW (1999) Laminar fiber architecture and three-dimensional systolic mechanics of canine ventricular myocardium. Am J Physiol 276 (Heart Circ Physiol 45):H595-H607

  4. Karlon WJ, Covell JW, McCulloch AD, Hunter JJ, Omens JH (1998) Automated measurement of myofiber disarray in transgenic mice with ventricular expression of ras. Anat Rec 252:612-625.

1998

(Top»)

  1. Emery JL, Omens JH, Mathieu-Costello OA, McCulloch AD (1998). Structural mechanisms of acute ventricular strain softening. Int J Cardiovasc Med Sci 1(3/4):241-250

  2. Omens JH, Vaplon SM, Fazeli B, McCulloch AD (1998) Left ventricular geometric remodeling and residual stress in the rat heart. J Biomech Eng 120(6):715-719

  3. Summerour SR, Emery JL, Fazeli B, Omens JH, McCulloch AD (1998) Residual strain in ischemic ventricular myocardium. J Biomech Eng 120(6):710-714

  4. Bluhm WF, Sung D, Lew WY, Garfinkel A, McCulloch AD (1998) Cellular mechanisms for the slow phase of the Frank-Starling response. J Electrocardiol 31:13-22

  5. Hunter PJ, McCulloch AD, ter Keurs HEDJ (1998). Modelling the mechanical properties of cardiac muscle. Progress in Biophysics and Molecular Biology 69: 289-332.

  6. May-Newman KD, McCulloch AD (1998). Homogenization modeling for the mechanics of perfused myocardium. Progress in Biophysics and Molecular Biology 69:463-482

  7. Vetter FJ, McCulloch AD (1998). Three-dimensional analysis of regional cardiac anatomy. Progress in Biophysics and Molecular Biology 69:157-184

  8. Gregersen H, Emery JL, McCulloch AD (1998). History-dependent mechanical behavior of guinea-pig small intestine. Ann Biomed Eng 26:850-858.

  9. Mazhari R, Omens JH, Waldman LK, McCulloch AD (1998) Regional myocardial perfusion and mechanics: a model-based method of analysis. Ann Biomed Eng 1998;26:743-755 (and cover)

  10. Hennighausen H, Feldman ST, Bille JF, McCulloch AD. (1998) Anterior-posterior strain variation in normally hydrated and swollen rabbit cornea. Investigative Ophthalmology and Visual Science 39(2):253-62.

  11. McCulloch AD, Sung D, Wilson JM, Pavelec RS, Omens JH (1998). Flow-function relations during graded coronary occlusions in the dog: effects of transmural location and segment orientation. Cardiovasc Res 37:636-645.

  12. Bluhm WF, Lew WYW, Garfinkel AJ, McCulloch AD (1998). Mechanisms of length-history dependent tension in an ionic model of the cardiac myocyte. Am J Physiol 274(3 Pt 2):H1032-H1040.

  13. McCulloch AD, Bassingthwaighte JB, Hunter PJ, Noble D (1998) Computational biology of the heart: from structure to function. Progress in Biophysics and Molecular Biology 69:153-155

1997

(Top»)

  1. Lee, AA, McCulloch AD (1997) Multiaxial myocardial mechanics and extracellular matrix remodeling: mechanochemical regulation of cardiac fibroblast function. Advances in Experimental Medicine and Biology, 1997, 430:227-40

  2. Lee AA, McCulloch AD (1997) Multiaxial myocardial mechanics and extracellular matrix remodeling: mechanochemical regulation of cardiac fibroblast function. Adv Exp Med Biol 430:227-240. Chapter 19 in: Sideman S, Beyar R, (Eds). Analytical and Quantitative Cardiology. Plenum Press, New York.

  3. Costa KD, May-Newman KD, Farr DD, O’Dell WG, McCulloch AD, Omens JH (1997) Three-dimensional residual strain and stress in canine left ventricle. Am J Physiol 273 (Heart Circ Physiol 42): H1968-1976

  4. MacKenna DA, Vaplon SM, McCulloch AD (1997) Microstructural model of perimysial collagen fibers for myocardial mechanics during ventricular filling. Am J Physiol 273 (Heart Circ Physiol 42):H1576-H1586

  5. Emery JL, Omens JH, McCulloch AD (1997) Biaxial mechanics of the passively overstretched left ventricle. Am J Physiol 272(Heart Circ Physiol 41):H2299-H2305

  6. Emery JL, Omens JH, McCulloch AD (1997) Strain softening in rat left ventricular myocardium. J Biomech Eng 119(1):6-12

  7. Guccione JM, O'Dell WG, McCulloch AD, Hunter WC (1997) Anterior and posterior left ventricular sarcomere lengths behave similarly during ejection. Am J Physiol: Heart Circ Physiol 41(1):H469-477

1996

(Top»)

  1. Rogers JM, Courtemanche M, McCulloch AD (1996) Finite element methods for modeling impulse propagation in the heart. Chapter 7 in: Panfilov AV, Holden AV, eds. Computational Biology of the Heart. Sussex: John Wiley and Sons, Ltd.

  2. Costa KD, Hunter PJ, Wayne JS, Waldman LK, Guccione JM, McCulloch AD (1996) A three-dimensional finite element method for large elastic deformations of ventricular myocardium: Part II - Prolate spheroidal coordinates. J Biomech Eng 118: 464-472

  3. Costa KD, Hunter PJ, Rogers JM, Guccione JM, Waldman LK, McCulloch AD (1996) A three-dimensional finite element method for large elastic deformations of ventricular myocardium: Part I - Cylindrical and spherical polar coordinates. J Biomech Eng 118:452-463

  4. Lee AA, Delhaas T, Waldman LK, MacKenna DA, Villarreal FJ, McCulloch AD (1996) An equibiaxial strain system for cultured cells. Am J Physiol 271 (Cell Physiol 40): C1400-C1408

  5. Omens JH, Rodriguez EK, McCulloch AD (1996) Transmural changes in stress-free myocyte morphology during pressure overload hypertrophy in the rat. J Mol Cell Cardiol 28:1975-1983

  6. Omens JH, Farr DD, McCulloch AD, Waldman LK (1996) Comparison of two techniques for measuring two-dimensional strain in rat left ventricles. Am J Physiol 271(Heart Circ Physiol 40):H1256-1261.

  7. Waldman LK, Allen JJ, Pavelec RS, McCulloch AD (1996) Distributed mechanics of the canine right ventricle: effects of varying preload. J Biomech 29(3):373-382.

1995

(Top»)

  1. May-Newman KD, Mathieu-Costello OA, Omens JH, Klumb K, McCulloch AD (1995) Transmural distribution of capillary morphology as a function of coronary perfusion pressure in the resting canine heart. Microvasc Res 50:381-396.

  2. MacKenna DA, McCulloch AD (1995) Contribution of the collagen extracellular matrix to ventricular mechanics. In: Ingels NB, Daughters GT, Baan J, Covell JW, Reneman RS, Yin FC-P (Eds), Systolic and Diastolic Function of the Heart. IOS Press, Amsterdam and Ohmsha Ltd, Tokyo. Pages 35-46.

  3. Lee AA, Dillmann WH, McCulloch AD, Villarreal FJ (1995) Angiotensin II stimulates the autocrine production of transforming growth factor-β1 in adult rat cardiac fibroblasts. J Mol Cell Cardiol 27:2347-2357

  4. Guccione JM, KD Costa, McCulloch AD (1995) Finite element stress analysis of left ventricular mechanics in the beating dog heart. J Biomech 28(10):1167-1177

  5. McCulloch AD (1995) Cardiac Biomechanics. Chapter 31, Section III in: The Biomedical Engineering Handbook, Bronzino JD, Editor-in-Chief, CRC Press, Boca Raton, FL: pages 418-439.

1994

(Top»)

  1. Van Leuven SL, Waldman LK, McCulloch AD, Covell JW (1994) Gradients of epicardial strain across the perfusion boundary during acute myocardial ischemia. Am J Physiol 267:H2348-H2362

  2. Bluhm WF, McCulloch AD, Lew WYW (1994) Active force in rabbit ventricular myocytes. J Biomech 28:1119-1122

  3. Rogers JM, McCulloch AD (1994) Nonuniform muscle fiber orientation causes spiral wave drift in a finite element model of cardiac action potential propagation. J Cardiovasc Electrophysiol 5:496-509

  4. May-Newman KD, Omens JH, Pavelec RS, McCulloch AD (1994) Three-dimensional transmural mechanical interaction between the coronary vasculature and the passive myocardium in the dog. Circ Res 74:1166-1178

  5. Rogers JM, McCulloch AD (1994) A collocation-Galerkin finite element model of cardiac action potential propagation. IEEE Trans Biomed Eng 41:743-757

  6. MacKenna DA, Omens JH, McCulloch AD, Covell JW (1994) Contribution of the endomysial collagen matrix to passive left ventricular mechanics in the isolated rat heart. Am J Physiol 266:H1007-H1018

  7. Rodriguez EK, Hoger A, McCulloch AD (1994) Stress-dependent finite growth in soft elastic tissues. J Biomech 27:455-467

1993

(Top»)

  1. Waldman LK, McCulloch AD (1993) Nonhomogeneous ventricular wall strain: analysis of errors and accuracy. J Biomech Eng 115:497-502

  2. Rodriguez EK, Omens JH, McCulloch AD (1993) Effect of residual stress on transmural sarcomere length distribution in rat left ventricle. Am J Physiol 33:H1048-1056

  3. Omens JH, MacKenna DA, McCulloch AD (1993) Measurement of strain and analysis of stress in resting rat ventricular myocardium. J Biomech 26:665-676

  4. Guccione JM, Waldman LK, McCulloch AD (1993) Mechanics of active contraction in cardiac muscle: Part II. Cylindrical models of the systolic left ventricle. J Biomech Eng 115:82-90.

  5. Guccione JM, McCulloch AD (1993) Mechanics of active contraction in cardiac muscle: Part I. Constitutive relations for fiber stress that describe deactivation. J Biomech Eng 115:72-81

  6. Hashima AR, Waldman LK, Young AA, McCulloch AD (1993) Nonhomogeneous analysis of epicardial strain distributions during acute myocardial ischemia in the dog. J Biomech 26:19-35

1992

(Top»)

  1. McCulloch AD, Guccione JM, Waldman LK, Rogers JM (1992) Large-scale finite element analysis of the beating heart. In: Pilkington TC, Loftis B, Thompson JF, Woo SL-Y, Palmer TC, Budinger TF, Eds. High-Performance Computing in Biomedical Research. Boca Raton: CRC Press, pages 27-49

  2. McCulloch AD, Guccione JM, Waldman LK, Rogers JM (1992) Large-scale finite element analysis of the beating heart. Crit Rev Biomed Eng 20:427-449

  3. McCulloch AD, Hunter PJ, Smaill BH (1992) Mechanical effects of coronary perfusion in the passive canine left ventricle. Am J Physiol 262 (Heart Circ Physiol):H523-530

1991

(Top»)

  1. Omens JH, May KD, McCulloch AD (1991) Transmural distribution of three-dimensional strain in isolated arrested canine left ventricle. Am J Physiol 261 (Heart Circ Physiol 30):H918-928

  2. Guccione JM, McCulloch AD (1991) Finite element models of ventricular mechanics. In: Glass L, Hunter PJ, McCulloch AD, Eds. Theory of Heart: Biomechanics, Biophysics and Nonlinear Dynamics of Cardiac Function. New York: Springer-Verlag, pages 121-145.

  3. McCulloch AD, Omens JH (1991) Non-homogeneous analysis of three-dimensional transmural finite deformation in canine ventricular myocardium. J Biomech 24:539-548

  4. McCulloch AD, Omens JH (1991) Factors affecting the regional mechanics of the diastolic heart. Chapter 5 in: Glass L, Hunter PJ, McCulloch AD, Eds. Theory of Heart: Biomechanics, Biophysics and Nonlinear Dynamics of Cardiac Function. New York: Springer-Verlag, pages 85-120.

  5. Glass L, Hunter PJ, McCulloch AD (Eds) Theory of Heart: Biomechanics, Biophysics and Nonlinear Dynamics of Cardiac Function. New York: Springer-Verlag, 1991.

  6. Guccione JM, McCulloch AD, Waldman LK (1991) Passive material properties of intact ventricular myocardium determined from a cylindrical model. J Biomech Eng 113:42-55

Before 1990

(Top»)

  1. McCulloch AD, Smaill BH, Hunter PJ (1989) Regional left ventricular epicardial deformation in the passive dog heart. Circ Res 64:721-733

  2. McCulloch AD, Smaill BH, Hunter PJ (1987) Left ventricular epicardial deformation in the isolated arrested dog heart. Am J Physiol 252:H233-H241