Roy Kerckhoffs, PhD

Email: <roy AT SPAMFREE bioeng DOT ucsd DOT edu>

I earned my Ph.D. degree in biomedical engineering in 2003 at Eindhoven University of Technology in the Netherlands. Currently, I'm developing multi-scale (animal-specific and patient-specific) computational models of cardiac electromechanics to investigate the effects of cardiac resynchronization therapy on failing hearts.

My other major interest is photography.

Refereed journal papers

  1. Howard EJ, Kerckhoffs RCP, Vincent KP, Krishnamurthy A, Villongco CT, Mulligan LJ, McCulloch AD, Omens JH. Myofiber prestretch magnitude determines regional systolic function during ectopic activation in the tachycardia-induced failing canine heart. American Journal of Physiology – Heart and Circulation Physiology 2013, Accepted

  2. Krishnamurthy A, Villongco CT, Chuang J, Frank LR, Nigam V, Belezzuoli E, Stark P, Krummen DE, Narayan S, Omens JH, McCulloch AD, Kerckhoffs RCP. Patient-specific models of biomechanics. Journal of Computational Physics 244(1):4-21, 2013.

  3. Roy Kerckhoffs, Jeffrey Omens, Andrew McCulloch. Mechanical discoordination increases continuously after onset of left bundle branch block despite constant electrical dyssynchrony in a computational model of cardiac electromechanics and growth. Europace 14:v65-v72, 2012.

  4. Roy Kerckhoffs, Jeffrey Omens, Andrew McCulloch. A single strain-based growth law predicts concentric and eccentric cardiac growth during pressure and volume overload. Mechanics Research Communications 42:40-50, 2012.

  5. Roy Kerckhoffs. Computational Modeling of Cardiac Growth in the Post-Natal Rat with a Strain-Based Growth Law. Journal of Biomechanics 45:865–871, 2012.

  6. Dennis R. Trumble, Walter E. McGregor, Roy C.P. Kerckhoffs, and Lewis K. Waldman. Cardiac Assist with a Twist: Apical Torsion as a Means to Improve Failing Heart Function. Journal of Biomechanics 133(10):101003 (10 pages), 2011.

  7. Howard JH, Covell JW, Mulligan LJ, McCulloch AD, Omens JH and Kerckhoffs RCP. Improvement in pump function with endocardial biventricular pacing increases with activation time at the left ventricular pacing site in failing canine hearts. American Journal of Physiology – Heart and Circulation Physiology 301:H1447-H1455, 2011.

  8. Aguado-Sierra J, Krishnamurthy A, Villongco C, Chuang J, Gonzales MJ, Krummen DE, Narayan S, Kerckhoffs RCP, McCulloch AD. Patient-specific modeling of dyssynchronous heart failure: A case study. Prog Biophys Molec Biol 107(1):147-155, 2011.

  9. Roy Kerckhoffs, Jeffrey Omens, Andrew McCulloch, and Lawrence Mulligan. Ventricular dilation and electrical dyssynchrony synergistically increase regional mechanical non-uniformity but not mechanical dyssynchrony: A computational model. Circulation: Heart Failure 3: 528-536, 2010.

  10. Neal ML and Kerckhoffs RCP. Current Progress in Patient-Specific Modeling. Briefings in Bioinformatics 11(1):111-126, 2010. Invited Review.

  11. Stuart G. Campbell, Elliot Howard, Jazmin Aguado-Sierra, Benjamin A. Coppola, Jeffrey H. Omens, Lawrence J. Mulligan, Andrew D. McCulloch and Roy CP Kerckhoffs. Effect of Transmurally Heterogeneous Myocyte Excitation-Contraction Coupling on Three-Dimensional Ventricular Electromechanics. Experimental Physiology 94: 541-552, 2009.

  12. RCP Kerckhoffs, AD McCulloch, JH Omens, and LJ Mulligan. Effects of biventricular pacing and scar size in a computational model of the failing heart with left bundle branch block. Medical Image Analysis 13: 362-369, 2009.

  13. RCP Kerckhoffs, SM Narayan, JH Omens, LJ Mulligan, and AD McCulloch. Computational Modeling for Bedside Application. Invited paper. Heart Failure Clinics 4: 371-378. 2008

  14. RCP Kerckhoffs, J Lumens, K Vernooy, JH Omens, LJ Mulligan, T Delhaas, T Arts, AD McCulloch, FW Prinzen. Cardiac Resynchronization: insight from experimental and computational models. Progress in Biophysics and Molecular Biology 97: 543–561, 2008. Invited review.

  15. RCP Kerckhoffs, AD McCulloch, JH Omens, LJ Mulligan. Effect of Pacing Site and Infarct Location on Regional Mechanics and Global Hemodynamics in a Model Based Study of Heart Failure. FIMH07, Lecture Notes in Computer Science. 4466: 350-360, 2007

  16. RCP Kerckhoffs, M Neal, Q Gu, JB Bassingthwaighte, JH Omens, AD McCulloch. Coupling of a 3D finite element model of cardiac ventricular mechanics to lumped systems models of the systemic and pulmonic circulation. Annals of Biomedical Engineering. 35(1): 1-18, 2007.

  17. CM Ingrassia, TP Usyk, RCP Kerckhoffs, AD McCulloch, KD Costa, JW Holmes. Model-based development of four-dimensional wall motion measures. Computer Methods in Applied Mechanics and Engineering. 196: 3061-3069, 2007.

  18. RCP Kerckhoffs, SN Healy, TP Usyk, AD McCulloch. Numerical methods for cardiac electromechanics. Proceedings of the IEEE 94: 769-783, 2006. Invited review. (this is not a conference proceeding paper)

  19. RCP Kerckhoffs, OP Faris, PHM Bovendeerd, FW Prinzen, K Smits, ER McVeigh, T Arts. Electromechanics of the paced left ventricle simulated by a straightforward mathematical model: comparison with experiments. Am J Physiol Heart Circ Physiol. 289(5): H1889-1897, 2005.

  20. T Usyk, RCP Kerckhoffs. Three dimensional electromechanical model of porcine heart with penetrating wound injury. In Westwood JD et al eds. Studies in Health Technology and Informatics. Volume 111. Medicine Meets Virtual Reality 13. IOS Press, Netherlands 568-573, 2005

  21. T Delhaas, W Decaluwe, M Rubbens, R Kerckhoffs, T Arts. Cardiac Fiber Orientation and the Left-Right Asymmetry Determining Mechanism. Ann NY Acad Sci 1015: 190, 2004

  22. RCP Kerckhoffs, PHM Bovendeerd, FW Prinzen, K Smits, T Arts. Intra- and interventricular asynchrony of electromechanics in the ventricularly paced heart. J. Eng. Math. 47: 201-216, 2003

  23. RCP Kerckhoffs, OP Faris, PHM Bovendeerd, FW Prinzen, K Smits, ER McVeigh, T Arts. Timing of depolarization and contraction in the paced canine left ventricle: model and experiment. J. Cardiovasc. Electrophysiol. 14(10, suppl.): S188-S195, 2003

  24. L Geerts, RCP Kerckhoffs, PHM Bovendeerd, T Arts. Towards patient specific models of cardiac mechanics: a sensitivity study. Magnin et al (eds) FIMH 2003, Lecture Notes in Computer Science 2674: 81-90, 2003

  25. RCP Kerckhoffs, PHM Bovendeerd, JCS Kotte, FW Prinzen, K Smits, T Arts. Homogeneity of cardiac contraction despite physiological asynchrony of depolarization: a model study. Ann. Biomed. Eng. 31(5): 536-547, 2003

  26. T Arts, PHM Bovendeerd, A van der Toorn, L Geerts, RCP Kerckhoffs, FW Prinzen. Modules in cardiac modeling: mechanics, circulation, and depolarization wave. T Katila t al (eds) FIMH 2001, Lecture Notes in Computer Science 2230: 1-9, 2001

Book chapters

  1. Andrew D McCulloch and Roy CP Kerckhoffs. Cardiac Biomechanics. In: “The Biomedical Engineering Handbook”, 4th edition. Taylor & Francis Group, Boca Raton, FL. 2011. In Press.

  2. Jazmin Aguado-Sierra, Roy CP Kerckhoffs, Fred Lionetti, Darlene Hunt, Chris Villongco, Matt Gonzales, Stuart G Campbell, Andrew D McCulloch. A computational framework for Patient-Specific Multi-Scale Cardiac modeling. In: ''Patient-specific modeling of the cardiovascular system: Technology-driven personalized medicine''. Ed. Roy Kerckhoffs. Springer, New York. 2010.

  3. Roy Kerckhoffs and Lawrence J. Mulligan. Computational modeling of heart failure with application to cardiac resynchronization therapy. In: ''Computational Cardiovascular Mechanics: Modeling and Applications in Heart Failure'' Eds. Julius Guccione, Ghassan Kassab and Mark Ratcliffe. Springer, New York. 2010.

  4. Roy Kerckhoffs and Andrew McCulloch. Cardiac Electromechanics in the Healthy Heart. In: ''An Introductory Text to Bioengineering''. Eds. S. Chien, P.C. Chen and Y.C. Fung. World Scientific Publishing Co., Singapore. 2007.

Books

  1. Roy Kerckhoffs, editor. ''Patient-specific modeling of the cardiovascular system: Technology-driven personalized medicine''. Springer, New York. 2010.

  2. Roy Kerckhoffs, Barry Kerckhoffs. Landschaftspark Duisburg-Nord: Photosynthese. Lulu.com. 2010.

Teaching Experience

Guest lecturer for Freshmen course “Introduction to Bioengineering”, BENG 87, UCSD Bioengineering, “Computing electrical activation and mechanics in the paced heart”. March 2004

Seminar. UCSD Bioengineering. “Heterogeneity in the heart leads to homogeneous contraction. A model study”. 19 July 2004

Guest lecturer for Freshmen course “Introduction to Bioengineering”, BENG 87, UCSD Bioengineering, “Simulating cardiac pacing with computer models”. February, 2005, 2006

Guest lecturer for Freshmen course “Introduction to Bioengineering”, BENG 87, UCSD Bioengineering, “Modeling heart failure”. February 2007-2009

Guest lecturer for Continuity Summer School. August 2007 - 2009.

Guest Lecturer for undergraduate class “Biomechanics”, BENG 112A, UCSD Bioengineering, “Soft Tissues”. January 2009

Mentor in PRIME (Pacific Rim Undergraduate Experience) program. 2006 – 2011.

Lecturer of senior undergraduate class “Computer-aided analysis and design”, MAE150, UCSD Dept. Mechanical and Aerospace Engineering. Spring 2008. 77 students. Recommendation rating by students was 84% for me and class.

Guest Lecturer for graduate class “Cardiovascular Physiology” on physiology and modeling of the circulation. BENG 230C, UCSD Bioengineering, Spring 2009 and 2010.

Guest Lecturer for graduate class “Numerical Analysis for Multiscale Biology” on biomechanics modeling in Continuity. BENG 276, UCSD Bioengineering, Spring 2010.

Guest Lecturer for graduate class “Foundations of biomechanics” on virtual work, strain energy functions. BENG 226, UCSD Bioengineering, Spring 2011

Guest Lecturer in “Introduction to Bioengineering”, BENG87, UCSD Bioengineering, “Electromechanical Coupling” in Fall quarter of 2011.