BENG 161A Bioreactor Engineering, Fall Quarter, 2007

Inst

Day

Date

#

Topic

Reading in Text

HW Out

HW Due

AS

Th

9/27/2007

1

Cloning, expression, and manufacturing human recombinant erythropoietin

1

JJ

Tu

10/2/2007

2

Chemical Reactions. Mass Action Kinetics. Allosteric Binding; e.g., hemoglobin.

3.1,3.2

#1

TA

3

problem solving.

JJ

Th

10/4/2007

4

Michaelis-Menten, Rapid Equilibrium Assumption. Quasi-Steady State.

3.3.1, 3.3.2

JJ

Tu

10/9/2007

5

Lineweaver-Burk plot. Enzyme Inhibition: Competitive, Non-competitive, Uncompetitive, Substrate Inhibition.

3.3.3, 3.3.4

#2

#1

TA

6

problem solving. Diffusion & Mass Transfer review.

JJ

Th

10/11/2007

7

Ex-Continuous Stirred Tank Reactor. Immobilized Enzymes.

3.4.1

JJ

Tu

10/16/2007

8

Diffusional Limitations in Imobilized Enzyme Systems. Dahmkohler Number.

3.4.2.1

#2

TA

9

problem solving. Sample problems. Quiz review.

3.5, 3.6, 3.7

JJ

Th

10/18/2007

10

Effectiveness Factor.

3.4.2.2

Tu

10/23/2007

11

Quiz #1

TA

12

problem solving.

HYM

Th

10/25/2007

13

Tour of Biogen Idec

HYM

Tu

10/30/2007

14

Cell Growth. Batch Reactors. Quantifying Cell Number and Mass. Monod Model. Yield & Maintenance Coefficients.

6.1, 6.2, 6.3

#3

TA

15

problem solving.

HYM

Th

11/1/2007

16

Substrate-limited Growth. Optimization of Growth. Continuous Culture

6.3.2, 6.4

HYM

Tu

11/6/2007

17

Scale-up, Operation and Control: Scale-up and its difficulties

10.2

#4

#3

TA

18

problem solving-MATLAB for systems of equations.

HYM

Th

11/8/2007

19

Bioreactor Instrumentation and Control,

10.3, 10.4

ST

Tu

11/13/2007

20

Process design/flow and industrial practices for commodity scale chemical production

#5

#4

TA

21

quiz review

ST

Th

11/15/2007

22

Medium selection, waste treatment and process economics

DC & AA

Tu

11/20/2007

23

Ideal Chemostat. Deviations from Ideality. Chemostat with Recycle. Multistage Chemostat.

9.1-9.3.2

#5

11/21/2007

24

no class

Th

11/22/2007

25

THANKSGIVING HOLIDAY

Tu

11/27/2007

26

Quiz #2

TA

27

Journal Review

RLS

Th

11/29/2007

28

Fed batch perfusion systems

9.3.3, 9.3.4

#6

DC & AA

Tu

12/4/2007

29

Product of animal cell culture. Sterilization. Mixed Cell Cultures.

9.4, 10, 12

TA

30

review

DC & AA

Th

12/6/2007

31

Genentech Tour

#6

Tu

12/11/2007

Final Exam (7:00pm - 10:00pm)

  • Reading in Text: Chapter # in Shuler & Kargi
    Inst: Instructor Initials