Beeler-Reuter Action Potential Propagation in a Ring

Description

  • In this example, we simulate action potential propagation in a ring. In a small section of the ring, the sodium channels are initialized to be refractory so that propagation is unidirectional.

Start Continuity

  • Launch the Continuity 6.4 Client
  • Go to File→Library→Search, select 2D_ring (ID: 1226), right-click, and select Load.

  • A dialog box will pop-up asking if you want to save your current problem (your current problem should be blank).
  • Click to select Save (without reset) and proceed

  • Click OK

The shortcut: Execute pre-written script to solve EP problem

  • Go to File→Scripts→ScriptManager

    • Select EPscript

    • Click Execute Selected

  • Several minutes should elapse while the Electrophysiology problem executes. You can track the progress of the simulation by opening the Python Shell.
  • The solution should render and play automatically.

Execute steps manually

  • Mesh→Calculate Mesh...

  • Mesh→Render Elements...

    • Click lines radio button

    • Click Render to display mesh lines

  • Mesh→Render Elements...

    • Click surfaces radio button

    • Click Render to display mesh surface

  • Click Electrophysiology→Solve→Initialize

    • This specifies the initial conditions for the ordinary differential equations at each point in the mesh.
  • Do a Send with File→Send

  • Click Electrophysiology→Solve→Integration

    • Set Duration to 40.0 (ms)

    • Set Step Size to 0.02 (ms)

    • Under Output tab, select Display solution every 20 steps

    • click OK to start solving

  • You may track progress of the simulation in the Python shell
  • When solution is complete, verify OpenMesh is the renderer

    • View→Change Renderer...

    • Press OK when the warning pops up.

    • If DejaVu is selected, click OpenMesh radio button

    • Click OK to change renderer

    • You will have to re-render all objects if you were originally using DejaVu

  • You may adjust the resolution of the rendered solution is by changing the number at View→Set Divisions...

  • The Number of Divisions: should be 6 by default, but you may change it to 10.

  • Go to Electrophysiology→Render→Render Solution
    • Set Min value to -80

    • Set Max value: to 0 or 10

    • Click OK to view an animated color map of voltage