I am a fifth-year graduate student at the University of California, San Diego, and work in the Cardiac Mechanics Research Lab under PI's Dr. Omens and Dr. McCulloch.
I have been working on developing an in vitro model of load induced hypertrophy in isolated cardiac tissue specimens obtained from genetically engineered mouse models of human cardiovascular disease. I have utilized this system to study the mechanisms of mechanotransduction in the heart.
Defects in the mechanotransduction pathway may lead to heart failure and dilated cardiomyopathy. Understanding the mechanisms of mechanotransduction, both biochemical and mechanical, may help identify therapeutic strategies for the prevention and treatment of heart failure and dilated cardiomyopathy
Jeffrey Omens Ph.D, Bioengineering/Medicine, Advisor
Andrew McCulloch Ph.D, Bioengineering, Co-Advisor
Masa Hoshijima M.D./Ph.D., Medicine
Richard Lieber Ph.D., Bioenginering/Orthopaedic Surgery
Wolfgang Dillman M.D., Medicine
Ph.D Dissertation Defense
August 21st, 2008 3pm!!! Location TBA
AutoCAD Designs of Cardiac Tissue Mechanics Setup