Email: <ahsieh AT ucsd DOT edu>
My research focuses on live cell imaging and computational modeling from the molecular to cellular level in order to:
Investigate how defects in cardiac cell-cell and cell-extracellular matrix complexes disrupt the structural integrity, electrical, mechanical and signaling functions in isolated murine cardiomyocytes.
Israeli, S., Hsieh, A. L., Patel, H., Roth, D., Ross, R.S. (2009) Integrin-Caveolin Crosstalk in the Cardiac Myocyte. Basic Cardiovascular Sciences Annual Conference 2009- Molecular Mechanisms of Cardiovascular Disease
Hsieh, A. L., Wang, Y., Ross, R.S., Berns, M.W., McCulloch, A.D. (2009) Mechanotransduction in Single Cardiac Myocyte Studied Using Laser Tweezers and FRET. 2009 Biophysical Society Meeting Abstracts. Biophysical Journal, Supplement, B458, Abstract, 1614-Pos
Taylor, S., Sun, C., Hsieh, A., Andon, N., Ghosh, S. A Sulfated, Phosphorylated 7 kDa Secreted Peptide Characterized by Direct Analysis of Cell Culture Media. Journal of Proteome Research. 2008 Feb;7(2):795-802. Epub 2008 Jan 9
Manso, A. M.; Hsieh, A. L. ; Thor, A. K. ; Perkins, G. A. ; Zemljic-Harpf, A. E. (2009) Expression of the Tight Junctional Protein Occludin in Cardiac Myocytes Suggests the Presence of a Novel Cardiac Junction. 2009 ASCB Meeting Abstract.